{"product_id":"flea-free-ectoline-duo-hond-20-40kg-pipet-2-stuks","title":"Flea Free Ectoline duo dog 20-40kg pipette 2 pieces","description":"\u003cb\u003eFlea Free Ectoline duo dog 20-40kg pipette\u003c\/b\u003e\u003cbr\u003e \u003cb\u003eRVG NL 116241 AV\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e Ectoline duo 268mg\/80mg spot-on solution for large dogs\u003cbr\u003e Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. Fipronil and its metabolite, fipronil sulfone, act on ligand-gated chloride channels, specifically the neurotransmitter gamma-aminobutyric acid (GABA)-gated channels, as well as the glutamate-gated desensitizing (D) and non-desensitizing (N) channels (Glu, uniquely gated chloride channels found only in invertebrates). These channels bind to the chloride channel and block the pre- and postsynaptic transfer of chloride ions across the cell membrane. This results in uncontrolled central nervous system activity, killing insects and acarids.\u003cbr\u003e\r \u003cbr\u003ePyriproxyfen is an insect growth inhibitor that works through juvenile hormone-analog activity. Pyriproxyfen sterilizes adult fleas and prevents the development of immature stages. The molecule prevents the proliferation of adult fleas through contact by inhibiting the development of their eggs (ovicidal activity), larvae, and pupae (larvicidal activity), which then disappear.\u003cbr\u003e If adult fleas ingest and\/or come into contact with pyriproxyfen, the molecule also sterilizes flea eggs during their development and before they are laid. The molecule prevents contamination of the environment of treated animals with the immature flea stages.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eWhat is this medicine used for?\u003c\/b\u003e\u003cbr\u003e To be used for flea infestations alone or in conjunction with tick infestation.\u003cbr\u003e\u003cbr\u003e Against fleas:\u003cbr\u003e Treatment and prevention of flea infestations (Ctenocephalides felis). One treatment prevents further infestations for 7 weeks.\r \u003cbr\u003ePrevention of the multiplication of fleas by preventing the development of adult fleas from flea eggs for 12 weeks after administration.\u003cbr\u003e\u003cbr\u003e Against sign:\u003cbr\u003e Treatment of tick infestations (Ixodes ricinus).\u003cbr\u003e A single treatment provides persistent acaricidal effectiveness against Ixodes ricinus for 2 weeks and against Dermacentor reticulatus and Rhipicephalus sanguineus for 4 weeks.\u003cbr\u003e If some species of ticks (Dermacentor reticulatus, Rhipicephalus sanguineus) are already present when the veterinary medicinal product is administered, not all ticks may be killed within the first 48 hours.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eDo not use in\u003c\/b\u003e\u003cbr\u003e Do not use in rabbits, as side effects and even death may occur.\u003cbr\u003e\u003cbr\u003e Do not use if you are known to be hypersensitive to the active substances or to any of the excipients.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eActive ingredients\u003c\/b\u003e\u003cbr\u003e Active ingredients 2.68 ml pipette:\u003cbr\u003e Fipronil 268.0 mg\u003cbr\u003e Pyriproxyfen 80.4 mg\u003cbr\u003e Excipients\u003cbr\u003e Butylhydroxyanisole 0.536 mg\u003cbr\u003e Butylhydroxytoluene 0,268 mg\u003cbr\u003e\u003cbr\u003e \u003cb\u003eExcipients\u003c\/b\u003e \u003cbr\u003eButylhydroxyanisole E320\u003cbr\u003e Butylhydroxytoluene E321\u003cbr\u003e Diethylene glycol monoethyl ether\u003cbr\u003e\u003cbr\u003e \u003cb\u003eDosage\u003c\/b\u003e\u003cbr\u003e Administer one 2.68 ml pipette per dog weighing 20 to 40 kg, corresponding to\u003cbr\u003e with the minimum recommended dose of 6.7 mg fipronil \/kg body weight and 2 mg\u003cbr\u003e pyriproxyfen\/kg body weight.\u003cbr\u003e\u003cbr\u003e Volume - Weight dog - Fipronil (mg) - Pyriproxyfen (mg)\u003cbr\u003e 0.67 ml - 2-10 kg - 67 - 20.1\u003cbr\u003e 1.34 ml - 10-20 kg - 134 - 40.2\u003cbr\u003e 2.68 ml - 20-40 kg - 268 - 80.4\u003cbr\u003e 4.02 ml - 40-60 kg - 402 - 120.6\u003cbr\u003e For dogs \u0026gt; 60 kg the appropriate combination of pipettes should be used.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eDirections for use\u003c\/b\u003e\u003cbr\u003e Remove the pipette from the blister pack. Hold the pipette upright. Tap the narrow end of the pipette to ensure all the contents are in the pipette reservoir.\r \u003cbr\u003eBreak off the tip of the spot-on pipette along the break line. Part the dog's coat in front of the shoulder blades until the skin is visible. Place the tip of the pipette directly against the skin and gently squeeze the pipette several times to empty it. If necessary, the contents of the pipette can be applied to one or two additional spots to prevent the product from falling off the skin or being applied too superficially into the coat, especially in large dogs.\u003cbr\u003e\u003cbr\u003e The treatment consists of one pipette, with the option to repeat the application monthly.\u003cbr\u003e For optimal control of flea and tick infestations and flea multiplication, the treatment schedule can be adapted to the epidemiological situation.\u003cbr\u003e\u003cbr\u003e Read the package leaflet before use.\u003cbr\u003e Read the package leaflet before use.\u003cbr\u003e Please note the maximum daily dosage.\u003cbr\u003e\u003cbr\u003e \u003cb\u003eResponsible for placing on the market\u003c\/b\u003e\u003cbr\u003e ALFAMED,\n 13ème rue – LID,\n 06517 Carros Cedex,\n France","brand":"Flea Free","offers":[{"title":"2 Pieces","offer_id":56829383475545,"sku":"955909","price":26.5,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0971\/4843\/6825\/files\/8713112004041_A1N1.png?v=1765447535","url":"https:\/\/cleanpharma.nl\/en\/products\/flea-free-ectoline-duo-hond-20-40kg-pipet-2-stuks","provider":"CleanPharma","version":"1.0","type":"link"}